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- -------------------------------------------------------------------------------------------------
- 13 PROPERTIES (x variables)
- 111 OBJECTS (n compounds)
- SOURCE: H. Kubinyi, J. Chemometrics 1996, 10, 119-133
- ORIGINAL REFERENCE: C. Hansch, C. Silipo, and E. E.
Steller,
J. Pharm. Sci. 64, 1186 - 1191 (1975)
- REMARKS: none
- THE DATA:
| log(1/C) |
I1 |
I2 |
I4 |
I7 |
I8 |
I9 |
I10 |
I13 |
I15 |
I17 |
I20 |
I4*I8 |
I8*I17 |
|
5.48
|
0
|
1
|
0
|
1
|
1
|
0
|
0
|
0
|
1
|
0
|
0
|
0
|
0
|
|
5.48
|
0
|
0
|
0
|
1
|
1
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
|
5.68
|
0
|
0
|
0
|
0
|
1
|
0
|
0
|
0
|
1
|
0
|
0
|
0
|
0
|
|
5.7
|
0
|
0
|
0
|
0
|
1
|
0
|
0
|
0
|
1
|
1
|
0
|
0
|
1
|
|
5.74
|
0
|
0
|
0
|
1
|
1
|
0
|
0
|
0
|
1
|
1
|
0
|
0
|
1
|
|
5.85
|
0
|
1
|
0
|
1
|
1
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
|
6
|
0
|
0
|
0
|
0
|
1
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
|
6.01
|
0
|
0
|
0
|
1
|
1
|
0
|
0
|
0
|
1
|
0
|
0
|
0
|
0
|
|
6.01
|
0
|
0
|
0
|
1
|
1
|
0
|
0
|
0
|
1
|
1
|
0
|
0
|
1
|
|
6.04
|
1
|
0
|
0
|
0
|
1
|
0
|
0
|
0
|
1
|
1
|
0
|
0
|
1
|
|
6.05
|
1
|
0
|
0
|
0
|
1
|
0
|
0
|
0
|
1
|
0
|
0
|
0
|
0
|
|
6.09
|
0
|
0
|
0
|
0
|
0
|
1
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
|
6.17
|
0
|
0
|
0
|
1
|
1
|
0
|
0
|
0
|
0
|
1
|
0
|
0
|
1
|
|
6.25
|
0
|
0
|
0
|
0
|
1
|
0
|
0
|
0
|
0
|
1
|
0
|
0
|
1
|
|
6.28
|
0
|
1
|
0
|
1
|
0
|
1
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
|
6.28
|
0
|
0
|
0
|
1
|
1
|
0
|
0
|
0
|
1
|
1
|
0
|
0
|
1
|
|
6.3
|
0
|
1
|
0
|
1
|
0
|
1
|
0
|
0
|
0
|
1
|
0
|
0
|
0
|
|
6.32
|
0
|
0
|
0
|
0
|
1
|
0
|
0
|
0
|
0
|
1
|
0
|
0
|
1
|
|
6.35
|
0
|
0
|
0
|
0
|
1
|
0
|
0
|
0
|
0
|
1
|
0
|
0
|
1
|
|
6.37
|
0
|
0
|
0
|
0
|
0
|
0
|
1
|
0
|
0
|
1
|
0
|
0
|
0
|
|
6.37
|
0
|
0
|
0
|
0
|
0
|
0
|
1
|
0
|
1
|
1
|
0
|
0
|
0
|
|
6.43
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
|
6.46
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
1
|
0
|
0
|
0
|
|
6.47
|
0
|
0
|
0
|
1
|
1
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
|
6.48
|
0
|
0
|
0
|
0
|
0
|
0
|
1
|
0
|
0
|
1
|
0
|
0
|
0
|
|
6.49
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
1
|
0
|
0
|
0
|
|
6.51
|
0
|
0
|
1
|
1
|
1
|
0
|
0
|
0
|
1
|
0
|
0
|
1
|
0
|
|
6.51
|
0
|
1
|
0
|
1
|
0
|
1
|
0
|
0
|
1
|
0
|
1
|
0
|
0
|
|
6.55
|
0
|
0
|
1
|
1
|
0
|
1
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
|
6.55
|
0
|
0
|
0
|
1
|
1
|
0
|
0
|
0
|
0
|
1
|
0
|
0
|
1
|
|
6.68
|
0
|
0
|
0
|
1
|
1
|
0
|
0
|
0
|
0
|
1
|
0
|
0
|
1
|
|
6.74
|
0
|
0
|
0
|
0
|
0
|
1
|
0
|
0
|
1
|
0
|
1
|
0
|
0
|
|
6.77
|
0
|
0
|
0
|
0
|
1
|
0
|
0
|
0
|
0
|
1
|
1
|
0
|
1
|
|
6.77
|
0
|
0
|
0
|
0
|
0
|
0
|
1
|
0
|
1
|
0
|
0
|
0
|
0
|
|
6.8
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
1
|
0
|
0
|
0
|
0
|
|
6.8
|
0
|
0
|
1
|
1
|
0
|
0
|
0
|
0
|
1
|
0
|
0
|
0
|
0
|
|
6.8
|
0
|
1
|
0
|
1
|
0
|
1
|
0
|
0
|
0
|
1
|
1
|
0
|
0
|
|
6.8
|
0
|
0
|
1
|
1
|
1
|
0
|
0
|
0
|
1
|
1
|
0
|
1
|
1
|
|
6.82
|
0
|
0
|
0
|
0
|
0
|
0
|
1
|
0
|
1
|
0
|
0
|
0
|
0
|
|
6.82
|
0
|
1
|
0
|
1
|
0
|
0
|
1
|
0
|
0
|
1
|
0
|
0
|
0
|
|
6.82
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
1
|
0
|
0
|
0
|
0
|
|
6.82
|
0
|
0
|
0
|
0
|
0
|
0
|
1
|
0
|
0
|
0
|
0
|
0
|
0
|
|
6.82
|
0
|
0
|
0
|
0
|
0
|
1
|
0
|
0
|
0
|
1
|
1
|
0
|
0
|
|
6.85
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
1
|
0
|
0
|
0
|
|
6.85
|
0
|
0
|
1
|
1
|
1
|
0
|
0
|
0
|
0
|
1
|
0
|
1
|
1
|
|
6.89
|
0
|
1
|
0
|
1
|
0
|
0
|
0
|
0
|
1
|
0
|
0
|
0
|
0
|
|
6.89
|
0
|
0
|
1
|
1
|
1
|
0
|
0
|
0
|
0
|
1
|
0
|
1
|
1
|
|
6.92
|
0
|
1
|
0
|
1
|
0
|
0
|
1
|
0
|
1
|
1
|
0
|
0
|
0
|
|
6.92
|
0
|
1
|
0
|
1
|
0
|
0
|
0
|
0
|
0
|
1
|
0
|
0
|
0
|
|
6.92
|
0
|
0
|
1
|
1
|
0
|
1
|
0
|
0
|
1
|
0
|
1
|
0
|
0
|
|
6.96
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
|
6.96
|
0
|
0
|
0
|
0
|
0
|
0
|
1
|
0
|
0
|
0
|
0
|
0
|
0
|
|
6.96
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
1
|
0
|
0
|
0
|
0
|
|
6.96
|
0
|
0
|
1
|
1
|
0
|
0
|
0
|
0
|
1
|
0
|
0
|
0
|
0
|
|
6.96
|
1
|
0
|
0
|
0
|
1
|
0
|
0
|
0
|
0
|
1
|
1
|
0
|
1
|
|
7
|
0
|
0
|
0
|
0
|
0
|
0
|
1
|
0
|
0
|
1
|
0
|
0
|
0
|
|
7
|
0
|
0
|
1
|
1
|
0
|
1
|
0
|
0
|
0
|
1
|
1
|
0
|
0
|
|
7
|
0
|
0
|
0
|
1
|
0
|
0
|
1
|
0
|
1
|
0
|
0
|
0
|
0
|
|
7.02
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
1
|
0
|
0
|
0
|
|
7.04
|
0
|
0
|
1
|
1
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
|
7.05
|
0
|
1
|
0
|
1
|
0
|
0
|
0
|
0
|
0
|
1
|
0
|
0
|
0
|
|
7.07
|
0
|
0
|
0
|
1
|
0
|
0
|
0
|
0
|
1
|
0
|
0
|
0
|
0
|
|
7.07
|
0
|
0
|
1
|
1
|
0
|
0
|
1
|
0
|
1
|
0
|
0
|
0
|
0
|
|
7.07
|
0
|
0
|
0
|
0
|
0
|
0
|
1
|
0
|
1
|
0
|
0
|
0
|
0
|
|
7.07
|
0
|
0
|
0
|
0
|
0
|
1
|
0
|
0
|
0
|
1
|
0
|
0
|
0
|
|
7.08
|
1
|
0
|
0
|
0
|
0
|
0
|
1
|
0
|
1
|
0
|
| |
