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Comparative models of human matrix metalloproteinases are available for download. Some programs do not read the structures with hydrogens, therefore the structures without hydrogens are also provided. The structures were created by Viera Lukacova and used in the studies:

bulletLukacova V., Zhang Y., Mackov M., Baricic P., Raha S., Calvo J.A., Balaz S.:
Similarity of binding sites of human matrix metalloproteinases.
Journal of Biological Chemistry 279 (2004) 14194-14200.
bullet Lukacova V., Zhang Y., Kroll D. M., Raha S., Comez D., Balaz S.:
A comparison of the binding sites of matrix metalloproteinases and tumor necrosis factor-
a converting enzyme: Implications for selectivity.
Journal of Medicinal Chemistry 48 (2005) 2361-2370.
   

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complete structures no hydrogens

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         MMP-19 xxxxxx xxxxxx
MMP-20 xxxxxx xxxxxx
MMP-21 xxxxxx xxxxxx
MMP-23 xxxxxx xxxxxx
MMP-24 xxxxxx xxxxxx
MMP-25 xxxxxx xxxxxx
MMP-26 xxxxxx xxxxxx
MMP-27 xxxxxx xxxxxx
MMP-28 xxxxxx xxxxxx

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Comparative models of MMPs 2 and 9-18 were published in Massova, I., Kotra, L. P., and Mobashery, S. (1998) Bioorg. Med. Chem. Lett. 8, 853–858.

Last Updated: June 6, 2005

 

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